Alopecia Areata

Γυροειδής Αλωπεκία

Alopecia Areata is an Autoimmune Dermatological Disease that affects 2% of the world population.

Although it does not cause physical pain or makes you feel sick, it can be a psychologically devastating disease. This autoimmune disease involves the loss of hair around the scalp, face and parts of the body. It can occur at any time without prior notice.

In Alopecia Areata, the Immune System attacks the substance in the follicles of your hair. So treatment plans must deal with the Autoimmune response that is happening.

Patients do not change their routine. On the contrary, they are gradually seeing it improve, along with their overall physical health.


Diagnosis of Real Causes & Treatment of Alopecia Areata

  • Gradual restoration of cellular function
  • Personalized therapeutic protocols, without chemical residues and excipients
  • Treating the real causes
  • Therapeutic formulas that work alone or in combination with any other medication
  • Adopting a Molecular / Therapeutic Nutrition Plan


There are medicines and creams that doctors often prescribe to help the regeneration of hair.

But most of the patients notice side effects and the only result is temporary hair growth.

There are also treatments that will help you boost your immune system, reduce inflammation and to correct nutrient deficiencies that may exacerbate the situation.


What is Alopecia Areata

Frequent symptoms

Alopecia Areata or spot baldness is an autoimmune disease that involves the immune system that attacks your hair follicles, leading to hair loss. The word Alopecia means “baldness” in Latin.

The amount of hair loss experienced by people with Alopecia areata varies. Some lose small, round patches of hair about one quarter of the total surface area, a phenomenon which is more common. Other patients experience extensive or total hair loss.


The most common symptoms of Alopecia Areata

Hair loss:

The most common area of hair loss is the scalp. Sometimes patients have hair loss in other parts of the body, such as the beard, eyebrows and eyelashes. Studies show that when patients develop Symptoms of spot baldness earlier in life, they experience more severe hair loss. This is especially true when hair loss begins within the first two decades of life.

However, the course of the disease can be unpredictable. Hair grows spontaneously in 80% of patients within the first year. But sudden relapses can happen at any time. Alopecia Areata involves fragmented hair loss, with one or more coin-sized gaps in the scalp or other areas of the body. Alopecia Areata can be converted to the other two types of Alopecia. This occurs in about 7% of patients with alopecia.

The two types of Alopecia that can develop in patients include:

Alopecia Areata Totalis: hair loss on the entire scalp (occurs in about 5% of cases)

Alopecia Areata Universalis: complete hair loss (occurs in about 5% of cases), all over the scalp, face and body, including areas such as eyebrows, eyelashes, hands, feet and pubic hair.


Nail changes:

Research shows that nail changes occur in 10% – 38% of patients with Alopecia. The severity of the changes corresponds to the extent of the hair loss.

Some common changes include cleft nails, rough nails, sandy nails and vertical backs or lines running from the base of the nail to the top.

Alopecia usually begins when a person is between 20 and 40 years old. But the symptoms of the disease can occur at any age.

Studies show that in 82-88% of cases, patients have their first Alopecia at an age of 40 years.

40% of patients develop symptoms at the age of 20 years. If the symptoms occur earlier in life, there is an increased risk of an extended illness.

Individuals with Alopecia areata also at risk for anxiety and depression, thyroid disease (including Hashimoto’s disease), Vitiligo, Atopy (enhanced immune response to common allergens, which may result in conditions such as Asthma and Eczema), Lupus, Psoriasis, Rheumatoid Arthritis and other Autoimmune Diseases.

Studies show that among Alopecia patients, 38-39% of them develop depressive signs and 39-62% of them develop generalized anxiety disorder.

These psychiatric disorders can develop before or after the onset of Alopecia symptoms. About half of the incidents are noticed after symptoms occur. In addition, research shows that stressful events occur before the onset of Alopecia in about 10% of adults and 10-80% of children with the disease.


Causes of Alopecia Areata and Risk Factors

In Alopecia, white blood cells – which are supposed to protect your body from foreign invaders such as viruses and bacteria – attack the cells of the rapidly growing hair follicles.

As a result, the hair follicles become smaller and slow down the production of hair.

Scientists believe that a combination of genes can predispose a person for Alopecia.

But unlike some genetic diseases, it is unlikely that a child will actually inherit all the genes needed to predispose to autoimmune disease.

According to a systematic review published in Clinical, Cosmetic, and Research Dermatology, in which researchers collected data from all studies published in English over a period of 51 years associated with alopecia, the percentage of genes inherited ranges from zero up to 8.6% of the disease.

Studies on identical twins suggest that environmental factors also play a role in the development of Alopecia.

A study published in the journal of the American Academy of Dermatology evaluated 11 sets of identical twins and three sets of sibling twins to determine the compliance rate of Alopecia.

The researchers found that there was a 55% comparison rate for the identical twins and a zero for the other twins. This supports a genetic factor as the cause of Alopecia. But it’s not 100 percent, so environmental impacts eventually have to play an important role in the development of the disease.

Some environmental factors, according to conventional medicine that may play a role in the development of Alopecia Areata, include viral infections, psychological stress and trauma.

Scientists believe that environmental factors perpetuate an inflammatory response that interacts with your hair follicles and increases the body’s immune response.

This interaction activates the processes leading to hair loss. To explain this further, scientists point out the seasonal cycle of the disease and the increase in relapses in early spring, which occurs when there is an increase in viral infections.

Research also shows that people who have a family member with other autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, lupus, Addison’s disease or thyroid disease have an increased risk of developing Alopecia.

Treatment of Alopecia Areata

There is no definitive cure for Alopecia. The hair is usually regenerated on its own. The treatments make the hair grow faster and avoid recession.

Some of the most common conventional treatments for Alopecia Areata include:


The doctor injects local, infused or systemic corticosteroids to reduce inflammation and promote hair growth. Dermatologists usually use corticosteroid injections to treat Alopecia.

You should repeat the procedure every four to six weeks.This method of treatment does not prevent the occurrence of new hair loss. It is only used to help hair grow back into bald areas.

One side effect of corticosteroid infusions is that it can leave scars or cause atrophy on the skin after a treatment.

Some other side effects include discoloration of the color of the injection, pain at the injection site, and inflammation at the injection site.


Το Minoxidil (το οποίο βρίσκεται σε δημοφιλείς μάρκες απώλειας τρίχας όπως το Regaine®) είναι ένα φάρμακο ανάπτυξης τριχών που χρησιμοποιείται για να βοηθήσει τους ασθενείς να ξανακοιτάξουν τα μαλλιά τους.

Εφαρμόζεται τοπικά σε ενήλικες και παιδιά, διαδίδοντας το φάρμακο στην περιοχή της τριχόπτωσης, είτε είναι το τριχωτό της κεφαλής, το πρόσωπο ή το σώμα.

Η θεραπεία με μινοξιδίλη συνήθως συνδυάζεται με άλλο τύπο θεραπείας. Δεν είναι αποτελεσματική από μόνη της στη θεραπεία της εκτεταμένης τριχόπτωσης.


Anthralin is used to alter the immune function of skin. It is apllied topically for 20-60 minutes and then rinsed.

Anthralin cream is used to help hair return to bald areas. However, it can irritate the skin and even cause temporary discoloration of the skin.


Diphencyprone is applied topically to areas of hair loss to stimulate the immune system.

In fact, it causes a mild allergic reaction, sending white blood cells to the surface of the bald areas.The hope is that this combats inflammation at the affected areas and stimulates the hair follicles towards hair regeneration.

This type of immunotherapy is used to treat severe cases of Alopecia, including alopecia and alopecia universalis.


Immunosuppressants such as methotrexate and cyclosporin inhibit the immune response induced hair loss.

In a 2014 study evaluating the efficacy of methotrexate in Alopecia, the researchers found that hair regeneration of more than 50% occurred in 67% of patients.

Some side effects of taking immunosuppressants such as methotrexate include nausea, diarrhea, wounds, light skin and fatigue.


Alternative Treatments For Alopecia Areata

  1. Probiotics: The digestive system controls your immune system. That is why probiotics can help treat certain autoimmune conditions, including Alopecia. Researchers at the Massachusetts Institute of Technology found that feeding mice of oldage with probiotic bacteria to caused beneficial changes in the immune system. This resulted in healthier and younger hair and skin.Probiotic supplements can be used to improve your immune system so that your body does not overreact to perceived threats and cause inflammation.
  1. Zinc: Zinc can act as a natural treatment of Alopecia, because it helps to strengthen your immune system and restore your intestiral health, which is vital for normal immune responses. In addition, zinc is a vital metal for important hair follicle function. A 2016 study published in the International Journal of Dermatology found that lower serum zinc levels are common in patients with Alopecia, with zinc levels being lower in patients with severe cases of hair loss disease.Researchers suggest that zinc supplements can offer a therapeutic benefit, especially in patients with zinc deficiency.
  2. Quercetin: Quercetin is a type of antioxidant flavonoid known for its ability to reduce inflammation and fight free radical damage. It has strong effects on immunity and works to regulate downstream or suppress inflammatory pathways. This is why it is often used to treat symptoms associated with autoimmune disorders. A 2012 study in mice found that quercetin was effective in stimulating hair re-emergence compared to placebo injections. Scientists believe this is due to the anti-inflammatory properties of quercetin.
  1. Ginseng: Ginseng is a popular herbal medicine that contains various pharmacological compounds. It helps reduce inflammation and boost immune function. This helps the body maintain immune homeostasis. A 2012 study conducted by the Korean University College of Medicine found that red ginseng serves as an effective and natural cure for Alopecia. People who already receive corticosteroid injections can use them as a complementary treatment. There are many varieties of ginseng available today, including powdered, dried and tablet forms of Asian and American ginseng.
  1. Lavender Essential Oil: One of the many benefits of lavender oil includes its ability to heal and protect the skin. It acts as a powerful antioxidant and reduces inflammation. A study, from a research group in Scotland, analysed the effect of aromatotherapy in alopecia and demonstrated that lavender oil and other beneficial essential oils for hair serve as an effective natural remedy for Alopecia.
  1. Rosemary Essential Oil: Rosemary oil is commonly used to enhance hair thickness and growth. It works by increasing cellular metabolism that stimulates hair growth. Research shows that applying rosemary oil topically can be just as effective as minoxidil, a conventional treatment for Alopecia. You can use rosemary oil to treat dandruff and dry scalp. Simply apply 2-3 drops of rosemary oil directly to the area of interest twice a day.
  1. Acupuncture: Acupuncture is used as a natural remedy for Alopecia Areata because it can reduce T1 cells that attack hair follicles and cause hair loss. It also works to stimulate hair follicles, reduce inflammation and increase blood circulation in the affected area. Acupuncture also works to reduce stress and depression.
  1. Anti-inflammatory diet: One of the most important features of treating an Autoimmune Disease is of course the consumption of therapeutic, nutritious foods that will work to reduce inflammation and allow your body to recover quickly.
  2. Anxiety Reduction: In order to treat hair thinning and Alopecia-related hair loss, it is important to reduce stress levels and allow your body to heal so that your hair can grow quickly. There are several blood pressure inhibitors that can help encourage blood circulation and promote hair growth. These include exercise (such as yoga), meditation, journaling and spending more time outdoors.

Causal Treatments of Alopecia Areata

According to Functional Medicine the main causes of Alopecia Areata are:

  • Thyroid dysfunction
  • Glycosylation (disorders of glucose metabolism)
  • Reduced tissue oxygenation levels
  • Hormonal imbalance
  • Deficiency of vitamins and micronutrients
  • Toxic charge
  • Stress (psychological or physical)
  • Chronic inflammation and “hidden” infections
  • Allergies


All these deficiencies and dysfunctions lead to biochemical divergence and imbalance in all human tissues and organs. Our cells are the smallest units of life, the groups of which create the tissues and organs of our body. Biochemical and hormonal balance or otherwise homeostasis is related to our state of health and can be repaired:

– Without “special diets” and privations

– Without taking chemicals and pharmaceuticals

– Treatments acting individually or in combination, without side effects

The homeostasis and the metabolic pathways depend on the uptake and absorption of foods as well as on the toxic compounds that enter the body.

Alopecia Areata as an Autoimmune Disease can be treated with the help of specialized tests that help understand the underlying causes that cause it and which disrupt the immune system.

The treatment of Alopecia Areata according to the system of Functional Medicine works exclusively and individually on the real causes.

Treatments for Autoimmune Diseases can be administered individually or in combination, at the discretion of the specialist, in Functional Medicine.

Therapeutic protocols are calculated with algorithms and fractions based on tests analyzes and indicators and are strictly personalized.

The biochemical aberration that leads to the mutation of the cells, so that they are eventually recognized as “foreign cells” by the Immune System and eventually lead to the development of Autoimmune Diseases, can be restired in a time period of at least six months.

Symptoms of Autoimmune Disease recede from the first months of treatment. The overall health levels are improving. Gradually, patients who additionally apply the instructions given at the end of treatment, reduce any chances of relapse to a minimum.




  • Schneider MR, Schmidt-Ullrich R, Paus R (2009) The hair follicle as a dynamic miniorgan. Curr Biol 19: R132-R142.
  • Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A (2019) The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther (Heidelb) 9: 51-70.
  • Guo EL, Katta R (2017) Diet and hair loss: Effects of nutrient deficiency and supplement use. Dermatol Pract Concept 7: 1-10.
  • Finner AM (2013) Nutrition and hair: Deficiencies and supplements. Dermatol Clin 31: 167-172.
  • Singh RK, Chang HW, Yan D, Lee KM, Ucmak D, et al. (2017) Influence of diet on the gut microbiome and implications for human health. J Transl Med 15: 73.
  • Scott KP, Gratz SW, Sheridan PO, Flint HJ, Duncan SH (2013) The influence of diet on the gut microbiota. Pharmacol Res 69: 52-60.
  • Vaughn AR, Notay M, Clark AK, Sivamani RK (2017) Skin-gut axis: The relationship between intestinal bacteria and skin health. World J Dermatol 6: 52-58.
  • Bowe WP, Joshi SS, Shalita AR (2010) Diet and acne. J Am Acad Dermatol 63: 124-141.
  • Dawber R (1989) Alopecia areata. Monogr Dermatol 2: 89-102.
  • Odom RB, Davidsohn IJ, William D, Henry JB, Berger TG (2006) Clinical diagnosis by laboratory methods. In: Elston Dirk M, Andrews’ Diseases of the Skin: Clinical Dermatology. Saunders Elsevier.
  • Brenner W, Diem E, Gschnait F (1979) Coincidence of vitiligo, alopecia areata, onychodystrophy, localized scleroderma and lichen planus. Dermatologica 159: 356-360.
  • Trink A, Sorbellini E, Bezzola P, Rodella L, Rezzani R, et al. (2013) A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata. Br J Dermatol 169: 690-694.
  • Clavaud C, Jourdain R, Bar-Hen A, Magali Tichit, Christiane Bouchier, et al. (2013) Dandruff is associated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp. PLoS One 8: e58203.
  • Rinaldi F, Pinto D, Marzani B, Rucco M, Giuliani G, et al. (2018) Human microbiome: What’s new in scalp diseases. J Transl Sci 4: 1-4.
  • Pinto D, Sorbellini E, Marzani B, Rucco M, Giuliani G, et al. (2019) Scalp bacterial shift in Alopecia areata. PLoS One 14: e0215206.
  • Ho BS, Ho EXP, Chu CW, Ramasamy S, Bigliardi-Qi M, et al. (2019) Microbiome in the hair follicle of androgenetic alopecia patients. PLoS One 14: e0216330.
  • Polak-Witka K, Rudnicka L, Blume-Peytavi U, Vogt A (2019) The role of the microbiome in scalp hair follicle biology and disease. Exp Dermatol.
  • L Nair, Z Dai, AM Christiano (2017) 649 Gut microbiota plays a role in the development of alopecia areata. Journal of Investigative Dermatology 137: S112.
  • Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, et al. (2004) Alopecia areata investigational assessment guidelines–Part II. National Alopecia Areata Foundation. J Am Acad Dermatol 51: 440-447.
  • Grice EA, Kong HH, Conlan S, Deming CB, Davis J, et al. (2010) Topographical and temporal diversity of the human skin microbiome. Science 324: 1190-1192.
  • Paulino LC, Tseng CH, Strober BE, Blaser MJ (2006) Molecular analysis of fungal microbiota in samples from healthy human skin and psoriatic lesions. J Clin Microbiol 44: 2933-2941.
  • Gao Z, Perez-Perez GI, Chen Y, Blaser MJ (2010) Quantitation of major human cutaneous bacterial and fungal populations. J Clin Microbiol 48: 3575-3581.
  • Klindworth A, Pruesse E, Schweer T, Jörg Peplies, Christian Quast, et al. (2013) Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies. Nucleic Acids Res 41: e1.
  • Takahashi S, Tomita J, Nishioka K, Hisada T, Nishijima M (2014) Development of a prokaryotic universal primer for simultaneous analysis of bacteria and archaea using next-generation sequencing. PLoS One 9: e105592.
  • Apprill A, McNally S, Parsons R, Weber L (2015) Minor revision to V4 region SSU rRNA 806R gene primer greatly increases detection of SAR11 bacterioplankton. Aquat Microb Ecol 75: 129-137.
  • Parada AE, Needham DM, Fuhrman JA (2016) Every base matters: assessing small subunit rRNA primers for marine microbiomes with mock communities, time series and global field samples. Environ Microbiol 18: 1403-1414.
  • Walters W, Hyde ER, Berg-Lyons D, Ackermann G, Humphrey G, et al. (2015) Improved bacterial 16S rRNA Gene (V4 and V4-5) and fungal internal transcribed spacer marker gene primers for microbial community surveys. mSystems 1.
  • Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, et al. (2011) Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci USA 108: 4516-4522.
  • Kozich JJ, Westcott SL, Baxter NT, Highlander SK, Schloss PD (2013) Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl Environ Microbiol 79: 5112-5120.
  • Vigetti D, Viola M, Karousou E, Rizzi M , Moretto P, et al. (2008) Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging. J Biol Chem 283: 4448-4458.
  • Castro-Quezada I, Román-Viñas B, Serra-Majem L (2014) The mediterranean diet and nutritional adequacy: A review. Nutrients 6: 231-248.
  • Rushton DH (2002) Nutritional factors and hair loss. Clin Exp Dermatol 27: 396-404.
  • Mubki T, Rudnicka L, Olszewska M, Shapiro J (2014) Evaluation and diagnosis of the hair loss patient: Part I. History and clinical examination. J Am Acad Dermatol 71: 415.
  • Spivak JL, Jackson DL (1997) Pellagra: An analysis of 18 patients and a review of the literature. Johns Hopkins Med J 140: 295-309.
  • Goldberg LJ, Lenzy Y (2010) Nutrition and hair. Clin Dermatol 28: 412-419.
  • Kato I, Vasquez A, Moyerbrailean G, Land S, Djuric Z, et al. (2017) Nutritional correlates of human oral microbiome. J Am Coll Nutr 36: 88-98.
  • Manam S, Tsakok T, Till S, Flohr C (2014) The association between atopic dermatitis and food allergy in adults. Curr Opin Allergy Clin Immunol 14: 423-429.
  • Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, et al. (2002) Acne vulgaris: A disease of Western civilization. Arch Dermatol. 138: 1584-1590.
  • Grossi E, Cazzaniga S, Crotti S, Naldi L, Di Landro A, et al. (2016) The constellation of dietary factors in adolescent acne: A semantic connectivity map approach. J Eur Acad Dermatol Venereol 30: 96-100.
  • Zouboulis CC, Jourdan E, Picardo M (2014) Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol 28: 527-532.
  • Zákostelská Z, Málková J, Klimešová K, Pavel Rossmann, Michaela Hornová, et al. (2016) Intestinal microbiota promotes psoriasis-like skin inflammation by enhancing Th17 response. PLoS One 11: e0159539.
  • Zhang C, Zhang M, Wang S, Han R, Cao Y, et al. (2010) Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 4: 232-241.
  • Turnbaugh PJ, Bäckhed F, Fulton L, Gordon JI (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3: 213-223.
  • Mu Q, Kirby J, Reilly CM, Luo XM, (2017) Leaky gut as a danger signal for autoimmune diseases. Front Immunol 8: 598.