New, innovative therapeutic approaches with Peptides
Medicine has evolved and continues to evolve rapidly. Among the various achievements and innovations of the Medical Science is the implementation of new therapies based on a combination of drug administration, which includes peptides.
Peptides are complex molecules, which are composed of two or more amino acids and are found normally in our body. Amino acids are the building blocks of proteins. A protein molecule may consist of tens to thousands of amino acids and at the same time consist of two or more peptide chains.
Peptides, depending on their function, can be categorized into groups, for example, glycopeptides, neuropeptides, antimicrobials and hormonal peptides.
Scientists have been studying the way peptides function in our body for many years.In 1953, Vincent Du Vigneuad studied oxytocin, a hormone that plays an important role in the reproductive processes of all living things.
What he managed is to isolate the specific substance and determine its chemical composition. In this way, the first peptide hormone was created, the amino acid sequence of which had been determined. The next major step in medical science came in 1965, when insulin was synthesized by Chinese scientists.
The role of peptides in our body
Peptides are microscopic molecules that can bind directly to cell receptors and function selectively and in a fully targeted manner, while the amino acid structures of which they are composed are simple.In this way, they facilitate communication between the cells, as they incorporate the role of signal and message transmitter and contribute to the mobilization of the cells, in order for them to function properly.
Most natural hormonal peptides and neurotransmitters act as “agonists” at their respective receptors. This practically means that the interaction of such a peptide with the receptor, leads to a response from a cell, tissue or organ of the human body. This property of peptides has been shown to be particularly useful in diseases where peptides function as “agonists”, for example insulin in diabetes or opioids in pain management.
Furthermore, peptides can operate as mediators, stimulants and even hormones.This is due to the fact that most peptides transmit signals to cells, aiming to activate the function of structural, molecular, cellular and biological activities. Some other peptides can operate as enzyme inhibitors or as antimicrobial compounds and can interfere with our body’s metabolic processes.
The use of Peptides in Medicine
Based on all of the above, natural peptides are of major importance for carrying out a host of physiological processes. They are present in the body of all living organisms and carry out specific biological activities. The specificity of these activities is determined by the original sequence and structure of the peptides.
Their functionalityandsmallsize have contributed to the integration of the peptides as a means of therapeutic approach. The molecular diversity and different modes of action of natural peptides explain the fact that peptides are now widely used for therapeutic purposes and can contribute to the treatment of a multitude of conditions.
Peptides are available on the pharmaceutical market and according to clinical trials are well tolerated. Since January 2015, more than 60 peptide-containing drugs have been approved by the US FDA, while 140 peptide drugs are being evaluated in clinical trials.
The role of peptides in the treatment of Autoimmune diseases
Many different peptides have been discovered, some of which help balance the function of our immune system. For this reason, they are often used to treat certain autoimmune diseases, such as Ulcerative Colitis and Crohn’s Disease, with excellent results.
More specifically, Thymosin A-1 and Thymosin B-4 are two peptides that are often administered to treat autoimmune diseases, as they effectively contribute to the regulation and strengthening of the immune system.Furthermore, they have a good effect on thyroid, Rheumatoid Arthritis, Fibromyalgia and Inflammatory Bowel Disease, and can gradually restore hair health.
Additional therapeutic properties of Peptides
It is a pioneering and revolutionary therapeutic approach for both Chronic and Metabolic diseases. There are, in fact, peptides used to treat neurodegenerative diseases (Dihexa, Cerebrolysin, Selank, Semax, Ipamorelin), to increase Libido, to reduce neuropathic pain, to treat metabolic syndrome and insulin resistance. Also, BPC (body protection compound) 157 is a peptide that is administered for cell regeneration, as it exponentially increases the healing rate. Peptides may also be administered for the following purposes:
- Anti-aging. Peptides are an important medical breakthrough for Anti-Aging. Some peptides are used to boost the immune system. A healthy immune system can help fight aging, as opposed to a deregulated immune system, which can accelerate cell aging.
- Increase in energy levels
- Decrease in body fat
- Reinforcement of the proper function of the intestine
- Amplification of bone and brain health
Peptides in treatment protocols
Peptide administration is a pioneering and revolutionary treatment for Chronic and Autoimmune Conditions. In pharmaceutical science, they are an excellent model of treatment because they provide maximum effectiveness. Many new drugs are synthesized from natural peptides and their formation lies in the natural biodiversity of their sequences and in the wide range of biological roles they play.
For these reasons, they are included as treatment protocols for various chronic diseases. Their administration is contraindicated only for pregnant women or for people who have active cancer.
It is important to clarify, of course, that peptides cannot replace other therapeutic approaches, which include restoring the balance of the hormonal system, supplying the body with all the necessary nutrients and changes in the patient’s lifestyle. Their positive effect in the treatment of Chronic and Autoimmune diseases is enhanced in hormonally balanced and detoxified patients, who have sufficient nutrients and are characterized by good intestinal health.
Thus, when the peptides are administered in combination with natural cell repair and generally with other therapeutic methods, they can further enhance the cellular biochemistry, for the best possible results for the benefit of the patient.
The extremely promising results of Peptides in patients with Chronic and Autoimmune diseases
Science has evolved to a great extent, which helps us to be constantly informed about new things and to formulate new therapeutic methods. We are constantly becoming more and more informed about the goals and roles of peptides and we are improving in terms of creating peptides that are administered for therapeutic purposes in patients with Chronic and Autoimmune diseases.
The results so far regarding the administration of peptides to patients with Chronic Diseases are extremely promising. It is an innovative therapeutic method characterized by selective action, increased strength, maximum safety and tolerance, while the standards of treatment protocols that are formed are targeted and personalized.
- Padhi, A. et al (2014) Antimicrobial peptides and proteins in mycobacterial therapy: current status and future prospects. Tuberculosis 94, 363-373.
- Robinson, S.D. et. al. (2014) Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. PLOS ONE 9, e87648.
- Kaspar, A.A. and Reichert, J.M. (2013) Future directions for peptide therapeutics development. Drug Discov. Today 18, 807-817.
- Transparency Market Research (2012) Peptide Therapeutics Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2012-2018. Transparency Market Research.
- Sheridan, C. (2012) Proof of concept for next-generation nanoparticle drugs in humans. Nat. Biotechnol. 30, 471-473.
- Manning, M.C. et. al. (2010) Stability of protein pharmaceuticals: an update. Pharm. Res. 27, 544-575.
- Shulte, I. et. al. (2005) Peptides in body fluids and tissues as markets of disease. Expert Rev. Mol. Diagn. 5, 145-157.
- Zhou, L. and Bohn, L.M. (2014) Functional selectivity of GPCR signaling in animals. Curr. Opin. Cell Biol. 27, 102-108.
- Drruscio, peptides-anti-aging-immune-health-dr-kevin-wallace, Peptides – Medical Breakthrough for Anti-aging and Immune Health with Dr. Kevin Wallace
- Kara Fitzgerald, Peptide Therapy: Ready for Prime Time FxMed?
- Incredible health center, Peptide Therapy and the Future of Functional Medicine
- Austin precision medicine, Peptides for Regeneration